Intractable diseases

Incurable diseases

Nature

Includes both diseases of unknown aetiology, with no established therapeutic remedies (and with the possibility of sequelae), and chronic diseases, which put a heavy social and economic burden on both the patient and the relatives. The definition may be narrowed to include only serious mental and physical disorders (progressive muscular atrophy and dystropy, etc), but may be extended to include: Behcet's disease, multiple sclerosis, myasthenia gravis, and others.

Incidence

Globally, intractable diseases—those resistant to standard medical treatments—affect millions, with the World Health Organization estimating over 50 million people living with treatment-resistant epilepsy and more than 10 million with drug-resistant tuberculosis as of 2022. These conditions are prevalent in both developed and developing regions, often leading to prolonged suffering, increased healthcare costs, and significant social and economic burdens.
In 2019, Japan reported over 300,000 cases of intractable diseases, including amyotrophic lateral sclerosis (ALS) and idiopathic pulmonary fibrosis, under its national registry. Patients faced limited therapeutic options, highlighting the persistent challenge of managing such conditions despite advanced healthcare infrastructure.

Claim

Intractable diseases represent a profound and urgent crisis that demands our immediate attention. These relentless conditions not only devastate the lives of millions but also strain healthcare systems and economies worldwide. The lack of effective treatments and research funding is unacceptable. We must prioritize innovative solutions and compassionate care for those suffering. Ignoring this issue is a moral failure; we owe it to patients and their families to confront the challenges posed by intractable diseases head-on.

Counter-claim

Intractable diseases, while challenging, should not dominate our focus. Society faces far more pressing issues, such as climate change, poverty, and education. Resources and attention should prioritize these global crises that affect millions daily. The narrative around intractable diseases often overshadows the urgent need for systemic change in healthcare access and prevention. By redirecting our efforts, we can create a healthier, more equitable world for all, rather than fixating on a relatively niche concern.