Genetic engineering efforts focus on modification of specific genes in the DNA structure of a species through identification of genes associated with specific biological functions. When genetic material is added or deleted, little attention is given to the modification of the overall DNA structure. In fact there has been very little research on the overall structure, especially since it has been recognized that long sequences of nucleotides appear not to be associated with any biological function. However some research indicates that there is a super-structure, best described through numerical analysis, determining the sequences of chains of nucleotides (TCAG), notably through those sequences seemingly without function. In effect the millions of nucleotides in the DNA tend to self-organize by privileging and optimizing their relative proportions according to the numerical series of Fibonacci and Lucas (whose effects have long been remarked in the characteristic spiralling of petals in particular species). In this way there are what amounts to large scale patterning (numerical resonances) through the DNA structure as a whole. Introduction, or removal, of foreign genetic material necessarily disrupts such patterning. Research has suggested that such disruption renders the DNA vulnerable to unpredictable mutations that are effectively facilitated. Early research indicates that this destabilization can lead to death.